Effects of acquisition protocol on advanced diffusion MRI measures

Background Several studies have suggested that advanced diffusion MRI (dMRI) measures derived through the analytic techniques of kurtosis imaging (DKI) and neurite orientation density dispersion (NODDI) might provide better sensitivity to predict progression Alzheimer’s disease (AD) when compared conventional single tensor imaging. Two popular simultaneous multislice (SMS) sequences, namely Disease Neuroimaging Initiative (ADNI)-3 Human Connectome Protocol (HCP) are currently widely used in acquisition such dMRI data. Since HCP sequences require a custom connectome scanner, several variants protocol compatible with clinical wide use. Before across globe understand AD, it is imperative whether absolute WM reproducible harmonization sites employing different protocols applicable. In this study, we hypothesize higher spatial angular resolution data will result quantification DKI NODDI metrics, as comparatively lower ADNI-3 sequences. Method A 32-year-old healthy male participant was scanned over five weeks, both Advanced (114 directions, 2mm3 isotropic, b-values = 500s/mm2, 1000s/mm2, 2000s/mm2) 2 sequence (1.5mm3 2mm3) 3 (500s/mm2, 2500s/mm2) 213 directions on 3T Skyra scanner. Total scan time for 11:37 minutes, CCF 18:41 1.5mm3 23:13 minutes. Various were computed all repetitions in-house. JHU atlas tracts mask extract values along each tract at run separately. Result As shown Figs 1-4, dMRI-derived underestimated most sequence, although they had less variance runs. Second, more protocols. Conclusion Acquisition parameters affect measures. Our suggest pooling various should be performed caution